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PhD Fellowship, Horizon 2020 Marie Skłodowska-Curie Project CARTNET - Computational Chemist


Histidine Kinases are bacterial proteins involved in bacterial sensing, signalling, antibiotic resistance development and represent an exciting novel target for antibiotic development, an area of urgent medical need.


As part of the Marie Curie European Training Network, CARTNET, a PhD Fellowship position is available to develop computational models of histidine kinases and their inhibitors (HKIs). The project will combine ODD's state-of-the-art drug discovery tools, commercial molecular modelling packages and involve computational method development to progress existing HKIs and discover new ones. The ultimate aim is to develop antibacterial compounds with a good resistance profile as candidate novel antibiotics. The project will involve interaction and collaboration with CARTNET Fellows from other disciplines (chemists, biologists), secondments, and training events at other institutions involved in the network. The overall aim of CARTNET is to train young researchers in Europe to address serious and global problems of antibiotic resistance.


The position is available at ODD's Oxford office and will involve the candidate registering for a PhD at the University of Buckingham. The role will initially be available for three years.


The ideal candidate will have a good degree in one of the following:

• Chemistry (preferably with some background in computational modelling)

• Cheminformatics 

• Computer science, combined with a sound understanding of chemical structure.


In addition, candidates should have good written and oral English with strong communication skills. Experience of scientific computing, especially within a Unix/Linux environment will be a particular advantage.


At the 1st day of employment, it is required that the candidates have not previously been awarded a PhD (or equivalent) and must be in the first four years of their research careers. Furthermore, the candidates must not have worked or studied in the UK for more than 12 months in the three years prior to the start of the employment.


Please apply with a curriculum vitae and covering letter, detailing your motivation in applying for this project. Applications should be should be received by 31-Dec-2017 and sent to: contactus@oxforddrugdesign.com. Questions regarding the post can be sent to the same address.


The project is part of the Marie Curie ETN training network (CARTNET) Employment is governed by UK law and is in compliance with the rules and regulations laid down by the EU’s Horizon 2020 Marie Curie Initial Training Networks.